Your requirement is impossible to fulfill: if there is a 0-day vulnerability in one of the image reading libraries you use, then your code may be exploitable when it tries to parse and sanitize the incoming file. By "presanitizing" as soon as the image is received, you'd just be moving the point of exploitation earlier rather than later.
The only thing that would help is to parse and sanitize incoming images in a sandbox, so that, at least, if there was a vulnerability, it would be contained to the sandbox. The sandbox could be a separate process running as an unprivileged user in a chroot
environment (or VM, for the very paranoid), with an interface consisting only of bytestream in, sanitized image out.
The sanitization itself could be as simple as opening the image with ImageMagick, decoding it to a raster, and reencoding and emitting them in a standard format (say, PNG or JPEG). Note that if the input and output are both lossy formats (like JPEG) then this transformation will be lossy.
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